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Dr. Jayanti Mani

Dr. Jayanti Mani

Consultant - Neurology


MBBS, MD (Gen Medicine), DM (Neurology)


Fellowship in Clinical Epilepsy and Neurophysiology at Cleveland Clinic Foundation

Speciality Interests



Dr. Jayanti Mani has set up the Epilepsy Programme at Kokilaben Hospital. She is responsible for the medical management of all the patients with seizures and epilepsy including selection of patients who will benefit from epilepsy surgery. Thirty five epilepsy surgeries have been performed at Kokilaben Hospital so far.

Dr. Mani had her entire medical training at the GS Medical College and KEM Hospitals in Mumbai. After completing the DM degree in Neurology, she worked as a lecturer in Neurology at the twin institutes for two years. During this period she was a visiting fellow at the Department of EEG and Clinical Neurophysiology, Kings College London with Dr. Colin Binnie and Dr. Charles Polkey. She had a 5 year stint as an Assistant Professor in Neurology at the Nizams Institute of Medical Sciences Hyderabad.

Her interest in epilepsy then took her to the Cleveland Clinic Foundation where she completed a two year fellowship in Clinical Epilepsy and Neurophysiology during years 2003-2005. Dr. Mani trained with stalwarts in the field of adult and paediatric epilepsy like Dr. Hans Luders and Dr. Elaine Wyllie. She won awards for her research during this period.

After her return to Mumbai in 2005, Dr. Mani had been working as a Consultant Neurologist and Epileptologist in Mumbai with attachments at Bombay Hospital and Research Centre and at Wockhardt Hospitals, Mulund. She set up the video EEG monitoring and Epilepsy Program at the Bombay Hospital in Mumbai. She facilitated several surgeries for intractable epilepsy during this period.

ACADEMICS/RESEARCH/AWARDS Dr Mani has spent almost her entire clinical career in teaching hospitals in India and abroad. She has maintained a keen academic and research interest in Neurology and Neurophysiology and has publications in national and international journals like Neurology, Neurology India and Seizure, and has also contributed chapters to international textbooks in Epilepsy.

She is also a member of several national and international organisations including the Indian Academy of Neurology, Indian Epilepsy Association, American Academy of Neurology and the American Clinical Neurophysiology Society.

Key Publications

Original Articles
Evidence For A Basal Temporal Visual Language Centre: Cortical Stimulation Producing Pure Alexia: J.Mani, B.Diehl, Z. Piao, S. Schuele, E. Lapresto, P. Liu, D. Nair, D. S. Dinner, and H. O. Luders Neurology 2008; 71(20):1621-7.

Wada Memory Asymmetry Scores and Postoperative Memory Outcome in Left Temporal Epilpepsy. Jun 2 2008. (Epub ahead of print) in Seizure : European Journal of Epilepsy

Postoperative Sseizures After Extratemporal Resections And Hemispherectomy In Pediatric Epilepsy. J. Mani, A. Gupta,E. Mascha, D. Lachhwani, K. Prakash, W. Bingaman, and E. Wyllie Neurology 2006;66 1038-1043

Multiple Sclerosis In The Neuro Imaging Era From Western India , J Mani, N Chaudhary, SH Ravat PU Shah , Neurology India , Vol 47:1,1999 p8-11

Childhood Absence Epilepsy With Tonic Clonic Seizures And EEG 3-4 Hz Spike And MultiSpike -Slow Wave Complexes; Linkage to Chromosome 8q24, Fong GC et al in

Dr Jayanti Mani: Pre surgical neuropsychological evaluation of a 23 year old man with h/o seizure disorder

Nishit had his first seizure at 6 years of age, he had headache, retching, head turning to the  righ followed by whole body shaking and loss of consciousness.  He was taken to a GP and by that time he had a generalized convulsion. He was started on AED therapy but the drug compliance was poor. Mom chose to opt for homeopathy.  After 1 ½ year, he had an episode where he complained of inability to see followed by eyes and head version to right and unresponsiveness for few minutes. This time she consulted an allopath and anti epileptic medications were started. AED’s were started regularly after this episode.

Several medications were tried over the years.  Nishit continued to have brief spells of visual blurring and vomiting once or twice a month, rarely in clusters of 3-4 a day.  Over the years, his seizure intensity and frequency have decreased with medications but complete seizure control has not been achieved. Currently, he gets 1-3 events per month and at times they occur in clusters. His current seizures are described as beginning with an aura (he cannot describe the sensation) followed by coughing and feeling of nausea with hand automatisms; he is drowsy post ictally.
He is presently on 3 different medicines for his seizures: T .Levipil 1500mg BID, T Valance 500-0-750,  Oxetal 600mg BID

The mother had taken Nishit to several  senior medical professionals in Mumbai and Delhi.  He also underwent a video EEGin 2009  to evaluate the seizures. Surgery was suggested but not  strongly recommended and he was continued on medications. Nishit and his mother finally came to the Epilepsy centre at KDAH in early 2014.

Educational and Occupational History
Nishit was reported to be a low average student through his school years. He was given some concessions in school in view of his recurrent seizures. He dropped out of college in his second year of graduation as he was finding it effortful to cope with academics. He is currently doing accounts work in an office and reports of no significant difficulties at work.

Psycho- Social History
Nishit’s mother reported that he a stubborn and short tempered individual. He is an introvert person and does not socialize much. He is mistrustful and insecure and takes long to get along with people.


Nishit underwent a comprehensive presurgical evaluation at KDAH.  Brain MRI showed a subtle lesion in the right temporal region of the brain.  While this lesion was not very clearly visualised on MRI. The Video EEG, ictal SPECT and PET brain scans  and the neuropsychological assessment for memory all pointed to the same area as the seizure focus.  The epilepsy team in KDAH reviewed all the tests and offered him a temporal lobectomy.

Surgery was done in October 2014.  Nishit has been seizure free since surgery till date (June 2016).  He is now on tapering doses of the medication and is a seizure free life.

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Speciality Interests