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Dr. Pradnya Gadgil

Consultant -Paediatric Neurologist and Epileptologist
MBBS, MRCPCH (UK), Fellowship in Complex Paediatric Epilepsy (UK)

Fellowships

  • Paediatric Neurology - Great Ormond Street Children's Hospital, London and P.D. Hinduja Hospital and Research Centre, Mumbai
  • Paediatric Epilepsy and Epilepsy Surgery - Great Ormond Street Children's Hospital, London

Expertise

  • Paediatric Neurology
  • Paediatric Epilepsy, especially Complex Epilepsy
  • Developmental disorders

Services Offered

Epilepsy , Cerebral Palsy; Developmental Delay (difficulties in walking/ speech, etc), Disorders of social communication (Autism, ADHD, Learning disorders), Neuromuscular disorders, Neurometabolic/ Neurodegenerative diseases, Headaches, Acute neurological conditions such as meningitis, GBS, Childhood stroke, ADEM, etc., The cutting-edge technology and infrastructure as well as multidisciplinary teamwork ensure patients with even complex and rare conditions are treated optimally. A few examples are: Video EEG- 2 suites with 128 channel Stereo EEG, 3T MRI machine and Paediatric neuroradiologists, Ictal SPECT/ PET scan and Nuclear medicine specialists, Functional neurosurgeon , Neuronavigation/ Intraoperative MRI, Intraoperative electrophysiological monitorings, For management of stroke and other cerebrovascular conditions:Interventional radiology, Genetics department, Biochemistry department

Dr. Pradnya Gadgil graduated from B.Y.L. Nair Hospital, Mumbai with honours. She completed her training in Paediatric medicine from UK. Thereafter she trained in Paediatric Neurology and Complex Epilepsy in London. She has worked in centres of excellence in her super-specialty. Great Ormond Street Hospital is a quaternary paediatric neurology centre with one of the best paediatric complex epilepsy services in the world. She has also worked as a Paediatric Neurology Fellow in P. D. Hinduja Hospital, Mumbai for 2 years thus giving her a very broad local experience as well.

KDAH Experience :

Complex Epilepsy :

Dr. Pradnya Gadgil has joined Kokilaben Dhirubhai Ambani Hospital as a full time consultant in Pediatric Neurology from 2013. She is passionate about management of surgically remediable epilepsies in children, such as cortical dysplasias, epilepsies resulting from gliotic scars, etc. This is a subgroup of potentially treatable epilepsies in what is otherwise a chronic and significantly life style limiting disease.

Dr. Gadgil specialises in

  • Presurgical evaluation of refractory epilepsy
  • Invasive monitoring for lesion negative/ multilesional epilepsy
  • Alternative solutions for refractory epilepsy - Ketogenic diet, etc

Developmental disorders:

Dr Pradnya Gadgil also initiated setting up of the Department of Developmental Disorders in conjunction with the already well-established department of neurorehabilitation.

This department has a multi disciplinary team of paediatric physiotherapists, occupational therapists, speech and language therapists, special educator, paediatric clinical psychologist and counsellors. This caters to a large group of patients with issues in walking, speaking, behaviour, learning, etc.

Doctor'sScorecard

  • Epilepsy > 6000 paediatric patients
    Developmental delay >7000 paediatric patients

  • Examiner for the Child Neurology Group, Mumbai's fellowship exam.
  • National coordinator for the Paediatric Epilepsy Training (PET) program- run in association with British Paediatric Neurology Association. In 2015 over 500 paediatricians across India were trained in basic management of epilepsy through these programs.
  • Dr Gadgil is actively associated with Samman, Mumbai sub chapter if Indian Epilepsy Association. She has piloted the 'Epilepsy School Awareness Program'. This generates awareness regarding epilepsy amongst school teachers of Mumbai- thus hoping to eventually educate the upcoming generations.
  • Dr Gadgil has organised MANDS training workshop in KDAH for parents of children with autism.
  • National Trainer for IAP Presidential Action Plan 2012 'Epilepsy and Movement Disorders' Module

Publications :

  • American Epilepsy Society 2016 Annual Meeting Poster presentation titled "Outcome of epilepsy surgery in a developing country in a heterogenous group of adults and children"
  • Vigabatrin-induced reversible changes on magnetic resonance imaging of the brain in Neurology India 2015 May-Jun
  • Nonparaneoplastic Anti-N-Methyl-D-Aspartate Receptor Encephalitis: A Case Series of Four Children in Paediatric Neurology 2012
  • Paediatric Epilepsy: The Indian experience in Journal of Paediatric Neurosciences 2011
  • Monograph-Infantile spasms in British Medical Journal- BMJ Point of Care October 2010
  • Management of Refractory Epilepsy in Childhood in Pediatric Therapeutics 2009
  • American Epilepsy Congress, Philadelphia 2007; Poster presentation "New onset refractory status epilepticus (NORSE) with generalized dyskinesia- a new ACTH responsive syndrome"
  • Co-authored 3 chapters in IAP Specialty Series on Rational Antimicrobial Practice In Pediatrics (Under IAP action plan 2006) - Penicillins and monobactams, Antifungals, Antimicrobial therapy in empyema thoracis

Awards :

'Best Award Paper' ECON 2010, Indore 'Vigabatrin induced MRI changes in infants'

Associations/Professional Membership :

  • Royal College of Paediatrics and Child Health, UK
  • Indian Academy of Paediatrics (Neurology Subchapter)
  • International League Against Epilepsy, UK
  • Indian Epilepsy Society
  • Samman and Indian Epilepsy Association

  • Bhavin Oza

    Dr Pradnya Gadgil is awesome. Very sweet approach towards kids and parents. She made them comfortable first and then reviewed the history of patient and accordingly started treatment.
  • Patient’s uncle (name withheld at request)

    Firstly Happy Rakshabandhan to you and supporting medical staff at the Hospital. Thank you and your medical team who performed treatment procedures of -patient AG and helped her come out from her physical problem since birth.
  • Awendi’s Mother

    Awendi is doing really well as we maintained the medication and intense therapy program you recommended. She started school and interacts really well with kids. The kids in school love her and play with her really well. Her eye contact has also improved a lot.
Dr. Pradnya Gadgil

Case 1: Epilepsy Surgery (Multilesional)

16-year-old girl came to Dr Pradnya Gadgil from West Bengal with history of frequent seizures since 8 years age. She was experiencing seizures 3-5 times every week. She had suffered from brain injury when she was extremely sick in newborn period requiring NICU admission. She had mild delay in developmental milestones but currently going to a mainstream school in 9th standard.

Multiple anti-epileptic medications were tried to no avail. The frequent seizures significantly limited her schooling, socialising with friends, participating in simple things like picnics, etc.

Parents had visited multiple hospitals in India and even abroad hoping for a cure. They were refused epilepsy surgery.

We performed a presurgical evaluation which included video EEG, Ictal SPECT scan, MRI brain with tractography and a neuropsychological evaluation.  MRI showed brain injury in multiple places. However, the evaluation revealed that we could treat her seizures by operating an area on the right side of the brain.There was a risk of her developing weakness post surgery – ideally we needed to perform awake surgery. The team (including her parents) felt this wasn’t possible.

Epilepsy surgery was performed using intraoperative monitoring- ECoG, Cortical stimulation, MEPs, etc. She woke up with weakness on one side but this improved to near normal in a few days of neurorehabilitation.

Her seizures have completely stopped since the surgery. She is now back to school-in 10th std.

This was a unique case as ideally this patient would have needed two-stage surgery. We managed to achieve seizure freedom with one-stage surgery. This was possible, as we have highly advanced techniques of intraoperative monitoring and a dedicated multi disciplinary epilepsy surgery team.

Case 2: Epilepsy surgery (Eloquent cortex dysplasia)

8-year-old boy came to Dr Pradnya Gadgil with history of seizures since 6 years of age. His seizures were not coming under control despite many anti-epileptic medications. His academic grades were also dropping. In addition to these problems, he was developing weakness of one side of his body. He had tests performed elsewhere, which showed a supposedly normal MRI.

We performed a detailed presurgical evaluation consisting of Video EEG, MRI brain, Functional MRI, Ictal SPECT, PET scan and neuropsychological evaluation. This revealed that a small area of the brain was malformed and was highly epileptogenic. Unfortunately, this was also the area, which was responsible for controlling movement of one side of his body. This was also the reason for his grades worsening (as his IQ was normal).

Parents were very keen on getting the surgery done despite significant possible risks. 

We planned a tailored resective epilepsy surgery with Dr Abhaya Kumar using intraoperative monitoring. This intraoperative monitoring done by Dr Gadgil enabled us to successfully resect the epileptogenic area of the brain without causing any complications.

Post surgery not only is the patient seizure free but his weakness has also improved.  He is able to use his right hand to write like before and has resumed normal schooling.

 

 

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