Dr. Pradnya Gadgil graduated from B.Y.L. Nair Hospital, Mumbai with honours. She completed her training in Paediatric medicine from UK. Thereafter she trained in Paediatric Neurology and Complex Epilepsy in London. She has worked in centres of excellence in her super-specialty. Great Ormond Street Hospital is a quaternary paediatric neurology centre with one of the best paediatric complex epilepsy services in the world. She has also worked as a Paediatric Neurology Fellow in P. D. Hinduja Hospital, Mumbai for 2 years thus giving her a very broad local experience as well.
Dr. Pradnya Gadgil has joined Kokilaben Dhirubhai Ambani Hospital as a full time consultant in Pediatric Neurology from 2013. She is passionate about management of surgically remediable epilepsies in children, such as cortical dysplasias, epilepsies resulting from gliotic scars, etc. This is a subgroup of potentially treatable epilepsies in what is otherwise a chronic and significantly life style limiting disease.
Dr. Gadgil specialises in
Dr Pradnya Gadgil also initiated setting up of the Department of Developmental Disorders in conjunction with the already well-established department of neurorehabilitation.
This department has a multi disciplinary team of paediatric physiotherapists, occupational therapists, speech and language therapists, special educator, paediatric clinical psychologist and counsellors. This caters to a large group of patients with issues in walking, speaking, behaviour, learning, etc.
| Epilepsy | > 6000 paediatric patients |
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| Developmental delay | >7000 paediatric patients |
'Best Award Paper' ECON 2010, Indore 'Vigabatrin induced MRI changes in infants'
Case 1: Epilepsy Surgery (Multilesional)
16-year-old girl came to Dr Pradnya Gadgil from West Bengal with history of frequent seizures since 8 years age. She was experiencing seizures 3-5 times every week. She had suffered from brain injury when she was extremely sick in newborn period requiring NICU admission. She had mild delay in developmental milestones but currently going to a mainstream school in 9th standard.
Multiple anti-epileptic medications were tried to no avail. The frequent seizures significantly limited her schooling, socialising with friends, participating in simple things like picnics, etc.
Parents had visited multiple hospitals in India and even abroad hoping for a cure. They were refused epilepsy surgery.
We performed a presurgical evaluation which included video EEG, Ictal SPECT scan, MRI brain with tractography and a neuropsychological evaluation. MRI showed brain injury in multiple places. However, the evaluation revealed that we could treat her seizures by operating an area on the right side of the brain.There was a risk of her developing weakness post surgery – ideally we needed to perform awake surgery. The team (including her parents) felt this wasn’t possible.
Epilepsy surgery was performed using intraoperative monitoring- ECoG, Cortical stimulation, MEPs, etc. She woke up with weakness on one side but this improved to near normal in a few days of neurorehabilitation.
Her seizures have completely stopped since the surgery. She is now back to school-in 10th std.
This was a unique case as ideally this patient would have needed two-stage surgery. We managed to achieve seizure freedom with one-stage surgery. This was possible, as we have highly advanced techniques of intraoperative monitoring and a dedicated multi disciplinary epilepsy surgery team.
Case 2: Epilepsy surgery (Eloquent cortex dysplasia)
8-year-old boy came to Dr Pradnya Gadgil with history of seizures since 6 years of age. His seizures were not coming under control despite many anti-epileptic medications. His academic grades were also dropping. In addition to these problems, he was developing weakness of one side of his body. He had tests performed elsewhere, which showed a supposedly normal MRI.
We performed a detailed presurgical evaluation consisting of Video EEG, MRI brain, Functional MRI, Ictal SPECT, PET scan and neuropsychological evaluation. This revealed that a small area of the brain was malformed and was highly epileptogenic. Unfortunately, this was also the area, which was responsible for controlling movement of one side of his body. This was also the reason for his grades worsening (as his IQ was normal).
Parents were very keen on getting the surgery done despite significant possible risks.
We planned a tailored resective epilepsy surgery with Dr Abhaya Kumar using intraoperative monitoring. This intraoperative monitoring done by Dr Gadgil enabled us to successfully resect the epileptogenic area of the brain without causing any complications.
Post surgery not only is the patient seizure free but his weakness has also improved. He is able to use his right hand to write like before and has resumed normal schooling.
| No. | Journal Code | Department | Type | Download | |
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| 1 | 95 | Centre for Children | National | Download | |
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Publication/Talk Title : Vigabatrin-Induced Reversible Changes on Magnetic Resonance Imaging of the Brain Journal Published : Neurology India |
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