Dr. Pradnya Gadgil

Dr. Pradnya Gadgil

Consultant, Paediatric Neurologist and Epileptologist; Director, Tuberous Sclerosis Clinic

MBBS, MRCPCH (UK), Fellowship in Complex Paediatric Epilepsy (UK)

  • Clinics: Autism Clinic, Cerebral Palsy Clinic
  • Support Groups: Epilepsy Patients
  • YEARS OF PRACTICE: 8 years
  • GENDER: Female
  • LANGUAGES SPOKEN: English, Hindi, Marathi
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Biography

Dr Pradnya Gadgil is a Paediatric neurologist and Epileptologist with special interests in complex epilepsy/ epilepsy surgery/ paediatric stroke and tuberous sclerosis. Dr Gadgil actively engages in projects which ‘action epilepsy’ outside the purview of a hospital. It ranges from collaborations for rural epilepsy camps to diagnose /treat kids with epilepsy free to organizing and/or teaching at scientific meetings both local and international.

My Mantra

I believe in doing best possible for every child and family. I am very aware of the limitations in treating sick children – medical, social, logistical, etc. However I am also aware that am privileged to be in a position to impact, influence and touch their lives in a positive way- big or small. The sweet innocent smiles and little hugs or hi-fives I get everyday is what keeps me going.

AREA(S) OF INTEREST:

Epilepsy; Epilepsy surgery; Paediatric Neurology, Paediatric Epilepsy, especially Complex Epilepsy and Epilepsy surgery, Tuberous Sclerosis, Paediatric Stroke, Autism and other Developmental disorders

PROCEDURES PERFORMED:

Epilepsy: Medical management, Epilepsy surgery, Ketogenic diet, VNS Implantation,
, Cerebral Palsy: CP Clinic includes Neurorehabilitation, Special Education, Multi-disciplinary inputs,
Childhood stroke: Emergency care ie Thrombolysis, Mechanical thrombectomy etc and Neurorehabilitation in long term,
Neurological emergencies: PICU care,
Autism/Developmental delays: Comprehensive and multi-disciplinary Paediatric Neurorehabilitation

TREATMENTS/PROCEDURES OFFERED:

Epilepsy, Cerebral Palsy; Developmental Delay (difficulties in walking/ speech, etc), Disorders of social communication (Autism, ADHD, Learning disorders), Neuromuscular disorders, Neurometabolic/ Neurodegenerative diseases, Headaches, Acute neurological conditions such as meningitis, GBS, Childhood stroke, ADEM, etc., The cutting-edge technology and infrastructure as well as multidisciplinary teamwork ensure patients with even complex and rare conditions are treated optimally. A few examples are: Video EEG- 2 suites with 128 channel Stereo EEG, 3T MRI machine and Paediatric neuroradiologists, Ictal SPECT/ PET scan and Nuclear medicine specialists, Functional neurosurgeon, Neuronavigation/ Intraoperative MRI, Intraoperative electrophysiological monitorings, For management of stroke and other cerebrovascular conditions:Interventional radiology, Genetics department, Biochemistry department

NAME OF INSTITUTE(S):

    • University of Mumbai
    • Royal College of Paediatrics and Child Health

FELLOWSHIPS:

    • Paediatric Neurology - Great Ormond Street Children's Hospital, London
    • Paediatric Epilepsy and Epilepsy Surgery - Great Ormond Street Children's Hospital, London and P.D. Hinduja Hospital and Research Centre, Mumbai 
  • Best Award Paper ECON 2010 (National Epilepsy Conference): 'Vigabatrin induced MRI changes in infants'
  • Best Doctor Paediatric: Top Docs Mumbai 2019 list

Dr. Pradnya Gadgil graduated from B.Y.L. Nair Hospital, Mumbai with honours. She completed her training in Paediatric medicine from UK. Thereafter she trained in Paediatric Neurology and Complex Epilepsy in London. She has worked in centres of excellence in her super-specialty. Great Ormond Street Hospital is a quaternary paediatric neurology centre with one of the best paediatric complex epilepsy services in the world. She has also earlier worked as a Paediatric Neurology Fellow in P.D Hinduja Hospital, Mumbai for 2 years thus giving her a very broad local experience as well.

KDAH Experience :

Dr. Pradnya Gadgil has set up the paediatric epilepsy service at KDAH. She is responsible for medical management of epilepsy in babies/ children/ young adults. She specializes in presurgical evaluation for difficult to control ie refractory epilepsy. She also has started the ketogenic diet and VNS service at KDAH for epilepsy – in fact one of the first VNS implantations in babies in Mumbai was done at KDAH.

In 2016 Dr Gadgil was instrumental in starting the Department for Developmental Disorders. The comprehensive nature makes it unique- we have not only paediatric therapists (physiotherapists, occupational therapists, speech and language therapists) but even special education/ paediatric psychologists/ counsellors. This treats children with developmental delay- cerebral palsy, autism, ADHD, Learning difficulty, ADHD, Down’s syndrome, other issues in walking/ speaking/ learning/behavior etc…

Dr Gadgil has initiated a novel concept- a day school in the hospital. It runs daily in the afternoon in the paediatric ward for benefit of kids admitted to the hospital.

  • Teacher/ Examiner: MUHS fellowship in Paediatric Epilepsy
  • Teacher: DNB Paediatrics at KDAH
  • National coordinator for Paediatric Epilepsy Training (PET) program- in association with British Paediatric Neurology Association
  • Co-Organiser of ‘Pathways to an Inclusive Life: International Autism conference’ February 2018
  • Part of the local organizing committee of 15th International Child Neurology Conference 2018 November 2018
  • Co-Organiser of International SEEG workshop Jan 2019
  • National Trainer for IAP Presidential Action Plan 2012 'Epilepsy and Movement Disorders' Module
  • Dr Gadgil is actively associated with Samman, Mumbai sub chapter of Indian Epilepsy Association where she
  • Piloted the 'Epilepsy School Awareness Program'
  • Core team conducting rural Epilepsy treatment camps at Dahanu

Publications

  • Explosive flurry of seizures and new-onset cortical-subcortical lesions in a patient with Wilson disease in Movement Disorders, vol. 33, S2, Oct 2018
  •  Vigabatrin-induced reversible changes on magnetic resonance imaging of the brain in Neurology India 2015
  • Nonparaneoplastic Anti-N-Methyl-D-Aspartate Receptor Encephalitis: A Case Series of Four Children in Paediatric Neurology 2012
  • Paediatric Epilepsy: The Indian experience in Journal of Paediatric Neurosciences 2011
  • Monograph-Infantile spasms in British Medical Journal- BMJ Point of Care October 2010
  • Management of Refractory Epilepsy in Childhood in Pediatric Therapeutics 2009
  • Co-authored 3 chapters in IAP Specialty Series on Rational Antimicrobial Practice In Pediatrics (Under IAP action plan 2006) - Penicillins and monobactams, Antifungals, Antimicrobial therapy in empyema thoracis

Prestigious Academic Presentations:

  • World Congress of Neurology 2019: Poster: Early experience with Stereoelectroencephalography from a Quarternary Hospital in India
  • International Child Neurology Conference 2018 (ICNC2018):
  • Platform presentation: Acute Childhood stroke: observations from case series of 45 children from tertiary center in Mumbai

Posters:

    Lacosamide responsive ESES (electrical status epilepticus in slow wave sleep)– 2 case reports

  • Anti NMDAr antibody mediated encephalitis: unusual presentation with focal motor deficits: 2 Pediatric case reports
  • Neurodevelopmental Assessment of Children and Adolescents with Neonatal Hypoglycemic Brain Injury (NHBI) to establish a developmental profile in the age group of Six years to Sixteen years: A Pilot Study
  • Assessment of Neurodevelopmental Status in Infants and Children with Neonatal Hypoglycemic Brain Injury– characterize the Spectrum of Neurodisability (6-42 months)- A Pilot Study
  • European Congress of Epileptology 2018 Vienna: Invited speaker
  • ‘Epilepsy surgery: Is non-invasive evaluation enough? Experience from a epilepsy unit in India’
  • AAN 2018: Poster: Seizure outcomes after epilepsy surgery using non invasive presurgical evaluation protocol: experience from a tertiary centre in India
  • MDS 2018: Poster:
  • AES 2016: Poster: ‘Outcome of epilepsy surgery in a developing country in a heterogenous group of adults and children’
  • ICNC 2014: Poster: SCN1A mutations in Indian patients with SCN1A-related epileptic disorders
  • AES 2007: Poster: ‘New onset refractory status epilepticus (NORSE) with generalized dyskinesia- a new ACTH responsive syndrome’

Professional Memberships

  • Royal College of Paediatrics and Child Health, UK
  • British Paediatric Neurology Association
  • Indian Academy of Paediatrics (Neurology Subchapter)
  • International Child Neurology Association
  • Indian Epilepsy Society and Indian Epilepsy Association (Samman)
  • Vaishali Gote, Raigad

    Excellent staff personnel and services rendered.  Doctors and nursing staff are very informative and transparent, follow protocol and are patient friendly. No suggestions. Overall a very good experience.

  • Bhavin Oza

    Dr Pradnya Gadgil is awesome. Very sweet approach towards kids and parents. She made them comfortable first and then reviewed the history of patient and accordingly started treatment.

    -Bhavin Oza

  • Patient’s uncle (name withheld at request)

    Dear Doctor Gadgil,

    Firstly Happy Rakshabandhan to you and supporting medical staff at the Hospital. Thank you and your medical team who performed treatment procedures of -patient AG and helped her come out from her physical problem ...

  • Awendi’s Mother

    Dear Dr Pradnya,

    Awendi is doing really well as we maintained the medication and intense therapy program you recommended. She started school and interacts really well with kids. The kids in school love her and play with her really we...

No. Journal Code Department Type Download
1 95 Center for Children National Download

Publication/Talk Title : Vigabatrin-Induced Reversible Changes on Magnetic Resonance Imaging of the Brain

Journal Published : Neurology India

Epilepsy > 6000 paediatric patients
Developmental delay >7000 paediatric patients

Dr. Pradnya Gadgil: Epilepsy Surgery (Multilesional)

Case 1: Epilepsy Surgery (Multilesional)

16-year-old girl came to Dr Pradnya Gadgil from West Bengal with history of frequent seizures since 8 years age. She was experiencing seizures 3-5 times every week. She had suffered from brain injury when she was extremely sick in newborn period requiring NICU admission. She had mild delay in developmental milestones but currently going to a mainstream school in 9th standard.

Multiple anti-epileptic medications were tried to no avail. The frequent seizures significantly limited her schooling, socialising with friends, participating in simple things like picnics, etc.

Parents had visited multiple hospitals in India and even abroad hoping for a cure. They were refused epilepsy surgery.

We performed a presurgical evaluation which included video EEG, Ictal SPECT scan, MRI brain with tractography and a neuropsychological evaluation.  MRI showed brain injury in multiple places. However, the evaluation revealed that we could treat her seizures by operating an area on the right side of the brain.There was a risk of her developing weakness post surgery – ideally we needed to perform awake surgery. The team (including her parents) felt this wasn’t possible.

Epilepsy surgery was performed using intraoperative monitoring- ECoG, Cortical stimulation, MEPs, etc. She woke up with weakness on one side but this improved to near normal in a few days of neurorehabilitation.

Her seizures have completely stopped since the surgery. She is now back to school-in 10th std.

This was a unique case as ideally this patient would have needed two-stage surgery. We managed to achieve seizure freedom with one-stage surgery. This was possible, as we have highly advanced techniques of intraoperative monitoring and a dedicated multi disciplinary epilepsy surgery team.

Case 2: Epilepsy surgery (Eloquent cortex dysplasia)

8-year-old boy came to Dr Pradnya Gadgil with history of seizures since 6 years of age. His seizures were not coming under control despite many anti-epileptic medications. His academic grades were also dropping. In addition to these problems, he was developing weakness of one side of his body. He had tests performed elsewhere, which showed a supposedly normal MRI.

We performed a detailed presurgical evaluation consisting of Video EEG, MRI brain, Functional MRI, Ictal SPECT, PET scan and neuropsychological evaluation. This revealed that a small area of the brain was malformed and was highly epileptogenic. Unfortunately, this was also the area, which was responsible for controlling movement of one side of his body. This was also the reason for his grades worsening (as his IQ was normal).

Parents were very keen on getting the surgery done despite significant possible risks. 

We planned a tailored resective epilepsy surgery with Dr Abhaya Kumar using intraoperative monitoring. This intraoperative monitoring done by Dr Gadgil enabled us to successfully resect the epileptogenic area of the brain without causing any complications.

Post surgery not only is the patient seizure free but his weakness has also improved.  He is able to use his right hand to write like before and has resumed normal schooling.

 

 

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