Dr Alka pursued her graduation and Post-graduation from B. J. Medical College, Pune.
She has worked as Anaesthetist at various organizations across Mumbai and Pune Nationally and London Internationally. Later she was associated with various reputable institutes across Mumbai as Consultant Cardiac Anesthetist. She was initially Member of Executive Council of IACTA and later joined as Member, Editorial Board Annals of Cardiac Anaesthesia since 1998 to 2012.
Meanwhile she was also appointed as CEO of Dr. Mandke's Memorial Cardiovascular Services Centre-2005 and Director & Trustee of Mandke Foundation and Malti Vasant Heart Trust since May 2005 till date
She has also been a part of Academic section imparting knowledge to graduation and Post-graduation students. She has been actively involved in Lectures, Panel Discussions, Workshops, Educational programmes and Presentations. She has been part of various National & International Conferences.
She has been part of Kokilaben Hospital- Unit of Mandke Foundation Since January 2009. She is Honorary Head of Anesthesia Department & Consultant Cardiac Anesthetist at Kokilaben Hospital.
Dr. Alka Mandke has written a book on life of her late husband ‘HRIDHAYASTH’ in 2004. It is translated in English, Hindi & Gujarathi on public demand.
Social programmes arranged on Occasion of Dr. Nitu Mandke Birth Anniversary on every year since 2004, 31st January, at Bharat Natya Mandir – Pune
Social programmes arranged on occasion of Dr. Nitu Mandke Death Anniversary every year – Since 2004
Indian Medical Association Pune and Indapur is named as Dr. Nitu Mandke IMA in 2017
She is now involved in social work through about 50 different NGOs and is member of advisory board of NGO Federation formed in 2018 at Pune, personally visited over 50 NGOs and helped. Chairperson of large NGO Keshavsrushti (RSS) at Uttan – Bhayander, Mumbai - an organization having day and residential International School, Krishividyalay and Krishisanshodhan Sanstha, Rambhau Mhalgi Prabodhini, Gaushala, Vanaushadhi Kendra and Vanprasthashram.