The relationship between stress and infertility is complex. Infertility can be a distressing and stressful experience for many couples. Stress can also interfere with ones wellness and manifest as physical and/or psychological symptoms. Undergoing infertility evaluation and treatment, and the associated decision-making process can add further stress to the frustration of being unable to conceive. Several published studies over the past 10 years have demonstrated that stress and anxiety have a negative impact on fertility, and that psychological interventions to reduce stress are associated with an overall improved quality of life and increased pregnancy rates.